Enzymic Synthesis and Regeneration of 3'-Phosphoadenosine 5'-Phosphosulfate (PAPS) for Regioselective Sulfation of Oligosaccharides

…, GJ Shen, E Garcia-Junceda, CH Wong

文献索引：Lin; Shen; Garcia-Junceda; Wong Journal of the American Chemical Society, 1995 , vol. 117, # 30 p. 8031 - 8032

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被引用次数: 45

摘要

Sulfated biomolecules play important roles in many biological processes.'The sulfated Lea tetra-and pentasaccharides, Ib for example, are potent inhibitors of the cell adhesion molecule P-seiectin, and sialyl Lewis x with a sulfate group at the 6-position of galactose is a ligand for L-selectin. Ic Many glycosaminoglycans such as heparin and dermatan sulfate are also sulfated and are involved in numerous cellular functions.'df In addition, the sulfation ...