Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin

…, S Yang, X Wu, E Studer, E Gurley, PB Hylemon…

文献索引：Liang, Guang; Li, Xiaokun; Chen, Li; Yang, Shulin; Wu, Xudong; Studer, Elaine; Gurley, Emily; Hylemon, Phillip B.; Ye, Faqing; Li, Yueru; Zhou, Huiping Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 4 p. 1525 - 1529

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被引用次数: 86

摘要

Curcumin has been extensively studied for its anti-inflammatory activities. However, its potential beneficial effects on various disease preventions and treatments are limited by its unstable structure. The β-diketone moiety renders curcumin to be rapidly metabolized by aldo–keto reductase in liver. In the present study, a series of curcumin analogues with more stable chemical structures were synthesized and several compounds showed an ...