Synthetic communications

Solvent free tetrahydropyranylation of alcohols and phenols over sulfuric acid adsorbed on silica gel

MM Heravi, M Ghassemzadeh

文献索引：Heravi, Majid M.; Ajami, Dariush; Ghassemzadeh, Mitra Synthetic Communications, 1999 , vol. 29, # 6 p. 1013 - 1016

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被引用次数: 54

摘要

Abstract Alcohols and phenols are tetrahydropyranylated in the presence of sulfuric acid adsorbed on silica gel in high to excellent yields in solvent free conditions and is expedited by microwave irradiation. Addition of methanol performs the complete deprotection ... The protection of hydroxy groups with 3,4-dihydro-2H-pyran (DHP) is a useful and outstanding method in organic synthesisl. More recently the tetrahydropyranylation process (THP ether synthesis) has ...