Tetrahedron Letters

Gold-catalyzed intramolecular hydroarylation of olefins. Scope evaluation and preliminary mechanistic studies

M Jean, P Van de Weghe

文献索引：Jean, Mickael; Van De Weghe, Pierre Tetrahedron Letters, 2011 , vol. 52, # 27 p. 3509 - 3513

全文：HTML全文

被引用次数: 17

摘要

Abstract We report a gold-catalyzed intramolecular hydroarylation of unactivated olefins using a combination of AuCl 3/AgOTf as the catalytic system affording dihydrobenzopyrans, tetralins and tetrahydroquinolines in good yields. For our preliminary mechanistic studies, we have investigated the kinetic isotope effects with deuterated arene compounds and found that this catalytic hydroarylation is consistent with an electrophilic aromatic ...