Expanding the scope of silane-mediated hydrodehalogenation reactions

…, BR Hayter, AD Campbell, TW Gorman, BE Partridge…

文献索引：Noonan, Gary M.; Hayter, Barry R.; Campbell, Andrew D.; Gorman, Timothy W.; Partridge, Benjamin E.; Lamont, Gill M. Tetrahedron Letters, 2013 , vol. 54, # 34 p. 4518 - 4521

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被引用次数: 5

摘要

Abstract A palladium-catalysed, silane-mediated hydrodehalogenation (HDH) reaction with increased substrate scope has been developed. Whereas previous attempts to reduce carboxylic acid or phenol-containing aryl halides using silane-based HDH conditions failed, the current protocol allows efficient access to the reduced products. Chemoselective HDH in the presence of sensitive functional groups is also presented.