Fluorine-18 labeled benzamides for studying the dopamine D2 receptor with positron emission tomography

…, RR Leudtke, CD Unsworth, VA Boundy…

文献索引：Mach; Leudtke; Unsworth; Boundy; Nowak; Scripko; Elder; Jackson; Hoffman; Evora; Rao; Molinoff; Childers; Ehrenkaufer Journal of Medicinal Chemistry, 1993 , vol. 36, # 23 p. 3707 - 3720

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被引用次数: 52

摘要

Two series of (N-benzylpiperidin-4-y1)-and (9-azabicyclo [3.3. 1lnonan-3~-yl) benzamides were prepared, and in vitro binding assays were used to measure the affinity of these compounds for dopamine D2, dopamine D3, serotonin 5-HT2, and a2-adrenergic receptors. The results of these studies indicated compounds 23, 26b, and 34 have the selectivity needed for in vivo studies of the D2 (and possibly D3) receptors. 18F-Labeled analogues ...