Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones

…, R Soni, JZ Patel, M Solanki, D Valani, S Gupta…

文献索引：Srivastava, Brijesh Kumar; Soni, Rina; Patel, Jayendra Z.; Solanki, Manish; Valani, Darshan; Gupta, Sunil; Mishra, Bhupendra; Takale, Vijay; Pandya, Purvi; Jain, Mukul R.; Patel, Pankaj R. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 18 p. 5227 - 5232

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被引用次数: 6

摘要

Design and synthesis of a few novel methylamino piperidinyl substituted oxazolidinones are reported. Their antibacterial activities have been evaluated in a MIC assay against broader panel of both susceptible and resistant Gram-positive strains.(S)-N-{3-[3-Fluoro-4-(methyl-{1- [3-(5-nitrofuran-2-yl)-acryloyl]-piperidin-4-yl}-amino)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}- acetamide 4i has shown comparable antibacterial activity to linezolid and eperezolid in ...