A facile circular dichroism protocol for rapid determination of enantiomeric excess and concentration of chiral primary amines

S Nieto, JM Dragna, EV Anslyn

文献索引：Nieto, Sonia; Dragna, Justin M.; Anslyn, Eric V. Chemistry - A European Journal, 2010 , vol. 16, # 1 p. 227 - 232

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被引用次数: 70

摘要

Abstract A protocol for the rapid determination of the absolute configuration and enantiomeric excess (ee) of α-chiral primary amines with potential applications in asymmetric reaction discovery has been developed. The protocol requires derivatization of α- chiral primary amines through condensation with pyridine carboxaldehyde to quantitatively yield the corresponding imine. The Cu I complex with 2, 2′-bis (diphenylphosphino)-1, 1 ...