Tetrahedron letters

A mild and practical deprotection method for benzyl thioethers

A Akao, N Nonoyama, N Yasuda

文献索引：Akao, Atsushi; Nonoyama, Nobuaki; Yasuda, Nobuyoshi Tetrahedron Letters, 2006 , vol. 47, # 30 p. 5337 - 5340

全文：HTML全文

被引用次数: 8

摘要

Deprotection of thiol groups is an essential step in the synthesis of sulfur-containing natural products and biologically active compounds. From the point of view of stability, the use of alkyl thioether protecting groups is advantageous, but deprotection of these groups requires harsh conditions. 1 and 2 For example, the deprotection of benzyl thioether, one of the most common protecting groups, requires the use of strong acids or bases, or reduction using alkali ...