Stereochemical requirements for β-hairpin formation: model studies with four-residue peptides and depsipeptides

TS Haque, JC Little, SH Gellman

文献索引：Haque, Tasir S.; Little, Jennifer C.; Gellman, Samuel H. Journal of the American Chemical Society, 1996 , vol. 118, # 29 p. 6975 - 6985

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被引用次数: 233

摘要

Spectroscopic and crystallographic data are presented for a series of tetrapeptides and analogous depsipeptides that can form a minimal β-hairpin (two intramolecular hydrogen bonds). These model compounds have been used to test the hypothesis that “mirror image” β-turns promote β-hairpin formation. This hypothesis was inspired by a statistical survey of β- hairpins in globular proteins (Sibanda, BL; Thornton, JM Nature 1985, 316, 170), which ...