New potent imidazoisoquinolinone derivatives as anti-Trypanosoma cruzi agents: Biological evaluation and structure–activity relationships

M Bollini, JJ Casal, DE Alvarez, L Boiani…

文献索引：Bioorganic and Medicinal Chemistry, , vol. 17, # 4 p. 1437 - 1444

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被引用次数: 29

摘要

... Bioorganic & Medicinal Chemistry. ... cells, compound 2 may decrease GSH levels irreversibly because TR is unable to reduce GSSG effectively, although another possibility is that GSSG might deplete T(SH) 2 , Tryparedoxin (Tpx), and/or TR as a result of chemical 21 or ...