Tetrahedron Letters

Towards the synthesis of epothilone A: Enantioselective preparation of the thiazole sidechain and macrocyclic ring closure

RE Taylor, JD Haley

文献索引：Taylor, Richard E.; Haley, Jeffrey D. Tetrahedron Letters, 1997 , vol. 38, # 12 p. 2061 - 2064

被引用次数: 91

摘要

A synthetic approach to a new class of microtubule-stabilizing natural products is described which employs a macrocyclic olefination strategy to cyclize the 16-membered lactone ring. The C13 C19 thiazole subunit of epothilone A and B is prepared in high enantioselectivity using a catalytic asymmetric allylation reaction.

6436-59-5

2-甲基噻唑-4-甲酸乙酯

~85%

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