Organic letters

An Efficient Total Synthesis of (−)-Epothilone B

J Wang, BF Sun, K Cui, GQ Lin

文献索引：Wang, Jie; Sun, Bing-Feng; Cui, Kai; Lin, Guo-Qiang Organic Letters, 2012 , vol. 14, # 24 p. 6354 - 6357

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被引用次数: 16

摘要

An efficient total synthesis of (−)-epothilone B has been achieved in ca. 8% yield over 11 steps from 9 (or 10 steps from 7/8), which features a bissiloxane-tethered ring closing metathesis reaction to approach the trisubstituted (Z) double bond and forms a new basis for