Pyrido [2, 3-d] pyrimidin-7-one inhibitors of cyclin-dependent kinases

…, M Quin, S Trumpp-Kallmeyer, P Toogood…

文献索引：Barvian; Boschelli; Cossrow; Dobrusin; Fattaey; Fritsch; Fry; Harvey; Keller; Garrett; La; Leopold; McNamara; Quin; Trumpp-Kallmeyer; Toogood; Wu; Zhang Journal of Medicinal Chemistry, 2000 , vol. 43, # 24 p. 4606 - 4616

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被引用次数: 153

摘要

The identification of 8-ethyl-2-phenylamino-8 H-pyrido [2, 3-d] pyrimidin-7-one (1) as an inhibitor of Cdk4 led to the initiation of a program to evaluate related pyrido [2, 3-d] pyrimidin- 7-ones for inhibition of cyclin-dependent kinases (Cdks). Analysis of more than 60 analogues has identified some clear SAR trends that may be exploited in the design of more potent Cdk inhibitors. The most potent Cdk4 inhibitors reported in this study inhibit Cdk4 ...