Pyrido [2, 3-d] pyrimidin-7-one inhibitors of cyclin-dependent kinases

…, M Quin, S Trumpp-Kallmeyer, P Toogood…

Index: Barvian; Boschelli; Cossrow; Dobrusin; Fattaey; Fritsch; Fry; Harvey; Keller; Garrett; La; Leopold; McNamara; Quin; Trumpp-Kallmeyer; Toogood; Wu; Zhang Journal of Medicinal Chemistry, 2000 , vol. 43, # 24 p. 4606 - 4616

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Citation Number: 153

Abstract

The identification of 8-ethyl-2-phenylamino-8 H-pyrido [2, 3-d] pyrimidin-7-one (1) as an inhibitor of Cdk4 led to the initiation of a program to evaluate related pyrido [2, 3-d] pyrimidin- 7-ones for inhibition of cyclin-dependent kinases (Cdks). Analysis of more than 60 analogues has identified some clear SAR trends that may be exploited in the design of more potent Cdk inhibitors. The most potent Cdk4 inhibitors reported in this study inhibit Cdk4 ...