Australian Journal of Chemistry

Synthetic studies related to mycobactins. III. Approaches to the synthesis of the cobactin ring system

DSC Black, RFC Brown, AM Wade

文献索引：Black,D.S.C. et al. Australian Journal of Chemistry, 1972 , vol. 25, p. 2429 - 2444

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被引用次数: 9

摘要

Abstract The synthesis of several seven-membered cyclic hydroxamic acids has been carried out in low yield. Reduction of diethyl 2-hydroxyiminoheptane-l, 7-dioate afforded ethyl 1-hydroxy-7-oxohexahydroazepine-2-carboxylate, together with related acyclic products. The cobactin precursor 3-bromo-1-hydroxyhexahydro-azepin-2-one was obtained by the ring expansion of 2-bromocyclohexanone with benzenesulphonohydroxamic acid ...