Synthesis and biological activity of some 2-imidazolinylhydrazone derivatives

A Kornicka, AL Hudson, PJ Bednarski

文献索引：Kornicka, Anita; Hudson, Alan L.; Bednarski, Patrick J. Acta Poloniae Pharmaceutica - Drug Research, 2009 , vol. 66, # 5 p. 523 - 534

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被引用次数: 8

摘要

Abstract: A series of N-(imidazolidin-2-ylidene) hydrazones and N-(4, 5-dihydro-1H-imidazol- 2-yl)-N-methylhydrazones were prepared and examined for α1-, α2-adrenergic and imidazoline I1, I2 receptors binding affinities as well as cytotoxic activity against human tumor cell lines. Among the compounds tested, 2-naphthaldehyde N-(imidazolidin-2- ylidene) hydrazone (3e) exhibited a significant affinity for both α2-adrenergic and ...