Tetrahedron

Setbacks and hopes: en route to the synthesis of uncialamycin

S Desrat, M Jean, P Van de Weghe

文献索引：Desrat, Sandy; Jean, Mickael; Van De Weghe, Pierre Tetrahedron, 2011 , vol. 67, # 39 p. 7510 - 7516

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被引用次数: 1

摘要

We herein report a new approach toward the synthesis of uncialamycin, an enediyne natural product isolated from the Streptomyces uncialis, bacteria present on the surface of the lichen Cladonia uncialis. A model for the preparation of uncialamycin has been achieved through a reaction cascade, an acetylide addition to the activated quinoline moiety, and a ring closure reaction as key steps.