Croatica chemica acta

3-amidoquinuclidine derivatives: Synthesis and interaction with butyrylcholinesterase

R Odžak, I Primožič, S Tomić

文献索引：Odzak, Renata; Primozic, Ines; Tomic, Srdanka Croatica Chemica Acta, 2007 , vol. 80, # 1 p. 101 - 107

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被引用次数: 1

摘要

Racemates as well as (R)- and (S)-enantiomers of 3-pivalamidoquinuclidine (PivQ) and 3-acet- amidoquinuclidine (AcQ) were prepared. Their quaternary racemic and enantiomerically pure N-benzyl derivatives (BnlPivQ and BnlAcQ) were synthesized as well. The amides were tested as substrates and inhibitors of butyrylcholinesterase (BChE) from horse serum (EC 3.1.1.8). No hydrolysis was observed under the experimental conditions applied. On the ...