Croatica chemica acta

3-amidoquinuclidine derivatives: Synthesis and interaction with butyrylcholinesterase

R Odžak, I Primožič, S Tomić

Index: Odzak, Renata; Primozic, Ines; Tomic, Srdanka Croatica Chemica Acta, 2007 , vol. 80, # 1 p. 101 - 107

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Abstract

Racemates as well as (R)- and (S)-enantiomers of 3-pivalamidoquinuclidine (PivQ) and 3-acet- amidoquinuclidine (AcQ) were prepared. Their quaternary racemic and enantiomerically pure N-benzyl derivatives (BnlPivQ and BnlAcQ) were synthesized as well. The amides were tested as substrates and inhibitors of butyrylcholinesterase (BChE) from horse serum (EC 3.1.1.8). No hydrolysis was observed under the experimental conditions applied. On the ...