Tetrahedron letters

A synthetic approach to the plakoridines modeled on a biogenetic theory

LL Etchells, A Sardarian, RC Whitehead

文献索引：Etchells, Laura L.; Sardarian, Ali; Whitehead, Roger C. Tetrahedron Letters, 2005 , vol. 46, # 16 p. 2803 - 2807

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被引用次数: 13

摘要

Plakoridines A and B (1 and 2) are two unusual, heterocyclic natural products which were isolated during the last decade from Okinawan marine sponges of the genus Plakortis. 1 and 2 These novel compounds have unprecedented structures which contain a tyramine unit and a fully substituted pyrrolidine ring system (Fig. 1). An elegant, 14-step asymmetric synthesis of (−)-plakoridine A has been reported by Ma and Sun 3 and this indicated that the natural products are ...