The Journal of Organic Chemistry

Formation and alkylation of anions of bis (methylsulfonyl) methane

A Castro, TA Spencer

文献索引：Castro, Alfredo; Spencer, Thomas A. Journal of Organic Chemistry, 1992 , vol. 57, # 12 p. 3496 - 3499

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被引用次数: 11

摘要

This study of the formation and alkylation of anions of al, &disulfone was undertaken to explore the idea that the disulfone moiety might serve as a surrogate for the diphosphate group in prospective inhibitors of the important enzymatic reactions which have substituted diphosphates as substrates. The diphosphate moiety itself is unsuitable as part of substrate analogue inhibitors in vivo because it is readily hydrolyzed by phosphates and because, ...