3-haloquinolines by friedlander reaction of α-haloketones

SV Ryabukhin, VS Naumchik, AS Plaskon…

文献索引：Ryabukhin, Sergey V.; Naumchik, Vasiliy S.; Plaskon, Andrey S.; Grygorenko, Oleksandr O.; Tolmachev, Andrey A. Journal of Organic Chemistry, 2011 , vol. 76, # 14 p. 5774 - 5781

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被引用次数: 30

摘要

A general approach to 3-fluoro-, 3-chloro-, and 3-bromoquinolines which relies on organosilane-promoted Friedländer reaction of α-haloketones is described. The scope of the methylene component as well as influence of the organosilane component on the outcome of the reaction is studied. The method can be used under parallel synthesis conditions.