Synthesis and antimicrobial activities of novel 1, 2, 4-triazolo [3, 4-a] phthalazine derivatives

QR Zhang, DQ Xue, P He, KP Shao, PJ Chen…

文献索引：Zhang, Qiu-Rong; Xue, Deng-Qi; He, Peng; Shao, Kun-Peng; Chen, Peng-Ju; Gu, Yi-Fei; Ren, Jing-Li; Shan, Li-Hong; Liu, Hong-Min Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 4 p. 1236 - 1238

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被引用次数: 4

摘要

Abstract A series of novel 1, 2, 4-triazolo [3, 4-a] phthalazine derivatives were synthesized in five steps from a common precursor, phthalic anhydride. Most of synthesized phthalazine derivatives showed inhibitory activity against Staphylococcus aureus. One of phthalazine derivatives 5l showed inhibitory activity against all tested bacterial and fungal strains.

51935-42-3

1-氯-4-肼基酞嗪

~80%

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~75%

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~87%

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Identification and synthesis of [1, 2, 4] triazolo [3, 4-a] ...

[Lebsack, Alec D.; Gunzner, Janet; Wang, Bowei; Pracitto, Richard; Schaffhauser, Herve; Santini, Angelina; Aiyar, Jayashree; Bezverkov, Robert; Munoz, Benito; Liu, Wensheng; Venkatraman, Shankar Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 10 p. 2463 - 2467]

6-(Alkylamino)-3-aryl-1, 2, 4-triazolo [3, 4-a] phthalazines...

[Tarzia, Giorgio; Occelli, Emilio; Toja, Emilio; Barone, Domenico; Corsico, Nerina; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1115 - 1123]