前往化源商城

6-(Alkylamino)-3-aryl-1, 2, 4-triazolo [3, 4-a] phthalazines. A new class of benzodiazepine receptor ligands

…, E Occelli, E Toja, D Barone, N Corsico…

文献索引:Tarzia, Giorgio; Occelli, Emilio; Toja, Emilio; Barone, Domenico; Corsico, Nerina; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1115 - 1123

全文:HTML全文

被引用次数: 55

摘要

Some 6-(alkylamino)-3-aryl-1, 2, 4-triazolo [3, 4-a] phthalazines have been shown to displace diazepam from rat brain specific binding sites, in vitro, with Ki (nM) values comparable to those of reference benzodiazepines and to have anticonvulsant (pentylenetetrazole test, mice) and anticonflict activity (Vogel test, rat) in vivo. Separation between the doses causing anticonflict effects (Vogel test, rat) and those impairing motor ...

 相关合成线路

~94%

~%

~%

~91%

~%

~%

~%

~54%

~%

~%

~88%

~%

~%

~77%

~%

~%

~%

~58%

~%

~%

~78%

~%

~%

~%

~79%

~%

~%

~89%

~%

~%

~%

~90%

~%

~%

~%

~57%

~%

~%

~%

~86%

~74%

~%

~%

~%

~82%

~%

~%

~%

~%

~67%

~%

~%

~%

~58%

~%

~%

~%

~72%

~%

~%

~70%

~%

~%

~87%

~%

~%

~73%

~%

~%

~%

~79%

~%

~%

~78%

~%

~%

~%

~88%

~%

~%

~%

~85%

~%

~%

~%

~68%

~%

~%

~%

~81%

~%

~%

~%

~90%

~%

~%

~84%

~%

~%

~76%