Directed ortho Metallation Chemistry and Phosphine Synthesis: New Ligands for the Suzuki-Miyaura Reaction

…, SJ Evans, H de Bod, MS Mokhadinyana, T Hughes

文献索引：Williams, D. Bradley G.; Evans, Stephen J.; De Bod, Henriette; Mokhadinyana, Molise S.; Hughes, Tanya Synthesis, 2009 , # 18 p. 3106 - 3112

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摘要

Abstract We describe the use of the phosphinic amide moiety as an effective directed ortho metallation group for the incorporation of various phosphino groups onto a benzene ring to generate phosphine ligands. These ligands were used to generate active palladium catalysts for the Suzuki-Miyaura reaction in which deactivated aryl bromides and some aryl chlorides were used as substrates. Surprisingly and interestingly, the (2-alkylphenyl) ...