Tetrahedron

Development of UV-responsive catch-and-release system of a cysteine protease model peptide

…, K Morishita, K Yamaguchi, H Ding, K Ebisuno, K Sato…

文献索引：Shigenaga, Akira; Morishita, Ko; Yamaguchi, Keiko; Ding, Hao; Ebisuno, Koji; Sato, Kohei; Yamamoto, Jun; Akaji, Kenichi; Otaka, Akira Tetrahedron, 2011 , vol. 67, # 46 p. 8879 - 8886

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被引用次数: 2

摘要

Cysteine proteases are attractive drug targets due to their involvement in a wide variety of diseases. To evaluate the potential of a particular protease as a drug target, use of a reagent that controls activity of the protease is indispensable. In this context, we have developed a catch-and-release reagent that first forms a covalent bond with the active center thiol of a cysteine protease to suppress its activity and then is removed by UV-irradiation to release ...