Tetrahedron

A facile preparation method for α, α-difluoroalkanecarboxylic acids and esters. A formal difluoromethylene insertion to alkanecarboxylic acids using radical reaction

T Okano, N Takakura, Y Nakano, A Okajima, S Eguchi

文献索引：Okano, Takashi; Takakura, Nobuyuki; Nakano, Yuko; Okajima, Asako; Eguchi, Shoji Tetrahedron, 1995 , vol. 51, # 7 p. 1903 - 1920

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被引用次数: 24

摘要

Various alkyl radicals generated by the photoreaction of a series of Barton esters reacted with 1, 1-dichloro-2, 2-difluoroethene to give radical adducts as the major product accompanied with self-trapping products. Primary, secondary, tertiary, benzyl, and some unsaturated alkyl radicals as well as those with another functional group such as ether, carbonyl, and azide were applicable. Barton esters of diacids also afford 1: 2 adducts with ...