Diversity??Oriented Approach to Normuscopyridine and Its Analogues through Ring??Closing Metathesis

…, GT Waghule, ME Shirbhate

文献索引：Kotha, Sambasivarao; Waghule, Gopalkrushna T.; Shirbhate, Mukesh E. European Journal of Organic Chemistry, 2014 , vol. 2014, # 5 p. 984 - 992

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被引用次数: 5

摘要

Abstract Ring-closing metathesis (RCM) is a useful protocol for assembling macrocycles. To synthesize normuscopyridine, and its analogues we used RCM as a key step in our strategy. Our approach to the synthesis of pyridine macrocycles involves two routes. The first approach starts with alkenylation of 2, 6-bis [(phenylsulfonyl) methyl] pyridine and involves five steps with 10% overall yield. The second route begins with Grignard addition to ...