Inhibition of monoamine oxidase by the R and S enantiomers of N [3-(2, 4-dichlorophenoxy) propyl]-N-methyl-3-butyn-2-amine

…, EM O'Brien, KF Tipton, M Meroni, P Melloni…

文献索引：Dostert, P; O'Brien, EM; Tipton, KF; Meroni, M; Melloni, P; Benedetti, M Strolin European Journal of Medicinal Chemistry, 1992 , vol. 27, # 1 p. 45 - 52

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被引用次数: 10

摘要

Abstract The chemical synthesis of the R-(+)-and S-(−)-enantiomers of N [3-(2, 4- dichlorophenoxy) propyl]-N-methyl-3-butyn-2-amine is described. These compounds are derivatives of the mechanism-based irreversible monoamine oxidase inhibitor clorgyline in which a methyl group is substituted for a hydrogen atom on the propargyl methylene carbon. The enantiomeric clorgyline derivatives were both found to be reversible, linearly- ...