Abstract The chemical synthesis of the R-(+)-and S-(−)-enantiomers of N [3-(2, 4- dichlorophenoxy) propyl]-N-methyl-3-butyn-2-amine is described. These compounds are derivatives of the mechanism-based irreversible monoamine oxidase inhibitor clorgyline in which a methyl group is substituted for a hydrogen atom on the propargyl methylene carbon. The enantiomeric clorgyline derivatives were both found to be reversible, linearly- ...
