Synthesis and Rhizopus oryzae mediated enantioselective hydrolysis of α-acetoxy aryl alkyl ketones

…, H Hamamci, C Tanyeli, IM Akhmedov, F Doganel

文献索引：Demir, Ayhan S.; Hamamci, Haluk; Tanyeli, Cihangir; Akhmedov, Idris M.; Doganel, Fatos Tetrahedron Asymmetry, 1998 , vol. 9, # 10 p. 1673 - 1677

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被引用次数: 54

摘要

Recently we have reported the synthesis of optically active α-hydroxy enones by lipase-catalyzed hydrolysis of α-acetoxy enones.[7]During the course of our studies on the biotransformation of acetoxy ketones to hydroxy ketones using different enzymes, we observed that Rhizopus oryzae has the versatility for the enantioselective hydrolysis of acetoxy ketones. ... In this paper we present the enantioselective synthesis of hydroxy ketones from ketones via Mn(OAc) 3 mediated ...