Trichosporon cutaneum-promoted deracemization of (±)-2-hydroxindan-1-one: a mechanistic study

T Cazetta, I Lunardi, GJA Conceição, PJS Moran…

文献索引：Cazetta, Tarcila; Lunardi, Ines; Conceicao, Gelson J.A.; Moran, Paulo J.S.; Rodrigues, J. Augusto R. Tetrahedron Asymmetry, 2007 , vol. 18, # 17 p. 2030 - 2036

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被引用次数: 9

摘要

A mechanistic study of the deracemization of (±)-2-hydroxy-1-indanone mediated by the yeast Trichosporon cutaneum to afford pure (1S, 2R)-1, 2-indandiol is reported. The key aspect of the study was the use of pure (R)-and (S)-2-hydroxy-1-indanone enantiomers to ensure reliable conclusions. Experiments in the absence of yeast cells or using dead cells disclosed that the pure enantiomers were not racemized, which suggest that the whole ...