Chemistry and pharmacological evaluation of 1??phenyl??2??propanols and 1??phenyl??2??propanones

…, JL Leseney, JP Long, JA Engelbrecht

文献索引：Barfknecht; Smith; Nichols; Leseney; Long; Engelbrecht Journal of pharmaceutical sciences, 1971 , vol. 60, # 5 p. 799 - 801

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被引用次数: 3

摘要

Abstract Various ring-methoxylated 1-phenyl-2-propanols and 1-phenyl-2-propanones were synthesized and pharmacologically evaluated. Most compounds had depressantlike activity. The ketones were readily reduced by rabbit liver microsomes. No reductase activity was found in rat and mouse liver preparations. Partition coefficients were determined, and a linear correlation between LRA 50′ s (loss of righting ability in 50% of the mice) and ...