Advanced Synthesis & Catalysis

Iridium (I)??Catalyzed Direct C H Bond Alkylation of the C??7 Position of Indolines with Alkenes

S Pan, N Ryu, T Shibata

文献索引：Pan, Shiguang; Ryu, Naoto; Shibata, Takanori Advanced Synthesis and Catalysis, 2014 , vol. 356, # 5 p. 929 - 933

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被引用次数: 37

摘要

Abstract: A cationic iridium-catalyzed C-7 alkylation of N-substituted indoline derivatives with various alkenes has been developed. A variety of 7-alkylACHTUNGTRENNUNGindolines were obtained in moderate to high yields. This protocol relies on the use of the carbonyl group on the nitrogen atom of indoline as a directing group and it is potentially applicable to the large-scale synthesis of 7-alkylindoles. Keywords: alkenes; alkylation; CÀH ...