Understanding the mechanism of B12-dependent diol dehydratase: a synergistic retro-push-pull proposal

DM Smith, BT Golding, L Radom

文献索引：Anderson, Rosaleen J.; Ashwell, Susan; Dixon, Ruth M.; Golding, Bernard T. Journal of the Chemical Society, Chemical Communications, 1990 , # l p. 70 - 72

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被引用次数: 82

摘要

Ab initio molecular orbital theory is used to investigate the coenzyme B12-dependent reactions catalyzed by diol dehydratase. The key step in such reactions is believed to be a 1, 2-hydroxyl migration, which occurs within free-radical intermediates. The barrier for this