Intramolecular functionalisation by a methylene radical of a 1, 2-diol and a vicinal amino alcohol: models for coenzyme B 12-dependent diol dehydratase and …

RJ Anderson, S Ashwell, I Garnett…

文献索引：Andersen, Rosaleen J.; Ashwell, Susan; Garnett, Ian; Golding, Bernard T. Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 24 p. 4488 - 4498

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摘要

Coenzyme B 12 -dependent diol dehydratase converts 1,2-diols (eg propane-1,2-diol) into the corresponding aldehyde and water. The similar enzyme ethanolamine ammonia lyase transforms vicinal aminoalcohols (eg 2-aminoethanol) into the corresponding aldehyde and ammonia. Model systems have been developed that replicate key features of the putative enzymatic mechanism, ie removal of a hydrogen atom from the CH 2 OH group of a 1,2-diol or ...