Synthesis of Oxovanadium Complexes and Their Apoptosis-Inducing Activity in Leukemia Cells

T Yamaguchi, S Watanabe, Y Matsumura…

文献索引：Yamaguchi, Tomoko; Watanabe, Shinya; Matsumura, Yuriko; Tokuoka, Yoshikazu; Yokoyama, Akihiro Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 4 p. 508 - 512

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被引用次数: 2

摘要

Vanadium complexes with different ligands were synthesized and evaluated for antiproliferative activity on U937 cells. The alkyl chain length of the ligands affected the antiproliferative activity, and two complexes—3b and 4—exhibited strong activities with IC 50 values of 6.02 and 3.90 μM respectively. Annexin V staining and DNA ladder formation indicated that these complexes induced apoptosis in U937 cells.