In this series, it appears that oxime derivatives are generally much more potent than their corresponding ether analogues. The most active compound 5, with a pA2= 8.7 on isolated guinea pig trachea, is as active as propranolol. Specifically, compounds 1, 3, and 6 are respectively ca. 20, 80, and 7 times more active on the isolated guinea pig atria and trachea than the ether analogues 12, 17, and 15. The dicyclopropyl oxime derivative 5 is ca. 6000 ...
