Synthesis and. beta.-adrenergic blocking activity of new aliphatic and alicyclic oxime ethers

…, N Decker, J Schwartz, G Andermann

Index: Bouzoubaa, Mohamed; Leclerc, Gerard; Decker, Nicole; Schwartz, Jean; Andermann, Guy Journal of Medicinal Chemistry, 1984 , vol. 27, # 10 p. 1291 - 1294

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Citation Number: 35

Abstract

In this series, it appears that oxime derivatives are generally much more potent than their corresponding ether analogues. The most active compound 5, with a pA2= 8.7 on isolated guinea pig trachea, is as active as propranolol. Specifically, compounds 1, 3, and 6 are respectively ca. 20, 80, and 7 times more active on the isolated guinea pig atria and trachea than the ether analogues 12, 17, and 15. The dicyclopropyl oxime derivative 5 is ca. 6000 ...