Stereochemical control in the addition of isothiocyanatoacetate esters to boron trifluoride activated 3-thiazolines. A novel synthesis of d-biotin

RA Volkmann, JT Davis, CN Meltz

文献索引：Volkmann, Robert A.; Davis, Jeffery T.; Meltz, Clifford N. Journal of the American Chemical Society, 1983 , vol. 105, # 18 p. 5946 - 5948

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被引用次数: 50

摘要

Determined by analysis of the gem-dimethyl region in the'H NMR of the crude reaction mixture. These values are consistent with the isolated product yields. Prepared by treatment of the corresponding glycine ester derivatives with thiophosgene." Prepared by the treatment ofN-[[(ethoxycarbonyl) thio]-thioxomethyl] glycine1* with TEA (1 equiv) followed by chloromethyl methyl ether (1 equiv). The glycine esters required for making these ...