Design, synthesis and anticancer activities of stilbene-coumarin hybrid compounds: Identification of novel proapoptotic agents

…, L Dal Bo, N Carenini, C Giommarelli, F Zunino

文献索引：Belluti, Federica; Fontana, Gabriele; Bo, Laura Dal; Carenini, Nives; Giommarelli, Chiara; Zunino, Franco Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 10 p. 3543 - 3550

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被引用次数: 133

摘要

The naturally occurring coumarins and resveratrol, attract great attention due to their wide range of biological properties, including anticancer, antileukemic, antibacterial and anti- inflammatory activities; moreover, their cancer chemopreventive property have been recently emphasized. A novel class of hybrid compounds, obtained by introducing a substituted trans- vinylbenzene moiety on a coumarin backbone, was synthesized and evaluated for the ...