Tetrahedron letters

Efficient synthesis of enantiomeric pairs of thiolactomycin and its 3-demethyl derivative

K Ohata, S Terashima

文献索引：Ohata, Kohei; Terashima, Shiro Tetrahedron Letters, 2006 , vol. 47, # 16 p. 2787 - 2791

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被引用次数: 19

摘要

(R)-(+)-Thiolactomycin (1) is a thiolactone antibiotic isolated from a soil bacterium, Nocardia sp. 1 and exhibits moderate in vitro activity against a number of pathogens including Gram-positive and Gram-negative bacteria, 2 Mycobacterium tuberculosis 3 and malaria parasites. 4 It was also reported that 1 shows inhibitory activity against fatty acid synthase (FAS). 5 In addition, it appeared that 1 inhibits bacterial and plant type-II FAS but not mammalian type-I FAS. 6 ...