Application of a Flexible Synthesis of (5 R)-Thiolactomycin To Develop New Inhibitors of Type I Fatty Acid Synthase

JM McFadden, SM Medghalchi…

文献索引：McFadden, Jill M; Frehywot, Gojeb L; Townsend, Craig A Organic letters, 2002 , vol. 4, # 22 p. 3859 - 3862

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被引用次数: 76

摘要

Fatty acid synthase (FAS) catalyzes the synthesis of palmitate from the sequential condensation of an acetyl primer with two carbon units added from malonyl-CoA. Inhibition of the β-ketoacyl synthase domain of mammalian FAS leads to selective cytotoxicity to