Fatty acid synthase (FAS) catalyzes the synthesis of palmitate from the sequential condensation of an acetyl primer with two carbon units added from malonyl-CoA. Inhibition of the β-ketoacyl synthase domain of mammalian FAS leads to selective cytotoxicity to
[Hof, Robert P.; Kellogg, Richard M. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 10 p. 1247 - 1250]
