Carboxylation of ketones using triethylamine and magnesium halides

RE Tirpak, RS Olsen, MW Rathke

文献索引：Tirpak, Robin E.; Olsen, Richard, S.; Rathke, Michael W. Journal of Organic Chemistry, 1985 , vol. 50, # 24 p. 4877 - 4879

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被引用次数: 56

摘要

Procedures for the carboxylation of ketones with carbon dioxide at atmospheric pressure in the presence of magnesium halides and triethylamine are described. A variety of ketones are converted to the corresponding P-keto acids in satisfactory yields by using magnesium chloride-sodium iodide mixtures in acetonitrile. This carboxylation reaction exhibits little regioselectivity with 2-butanone.