Identification of novel p38α MAP kinase inhibitors using fragment-based lead generation

AL Gill, M Frederickson, A Cleasby…

文献索引：Bristol, James A.; Gross, Irwin; Lovey, Raymond G. Synthesis, 1981 , # 12 p. 971 - 973

全文：HTML全文

被引用次数: 174

摘要

... 4-pyridyl)ethyl)indole 2 (IC 50 35 μM) were identified from X-ray crystallographic screening ... the lipophilic S1 subsite was achieved through compounds 6 and 7 which were synthesized from 2 ... role of amide and urea linkages from the central aromatic ring, the synthesis of several ...