Identification of novel p38α MAP kinase inhibitors using fragment-based lead generation

AL Gill, M Frederickson, A Cleasby…

Index: Bristol, James A.; Gross, Irwin; Lovey, Raymond G. Synthesis, 1981 , # 12 p. 971 - 973

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Citation Number: 174

Abstract

... 4-pyridyl)ethyl)indole 2 (IC 50 35 μM) were identified from X-ray crystallographic screening ... the lipophilic S1 subsite was achieved through compounds 6 and 7 which were synthesized from 2 ... role of amide and urea linkages from the central aromatic ring, the synthesis of several ...