Tetrahedron letters

Lactam acetals: Part XXIV reaction with activated haloalkyl compounds with and without zinc

S Jain, R Jain, J Singh, N Anand

文献索引：Jain, Sanjay; Jain, Rahul; Singh, Jujhar; Anand, Nitya Tetrahedron Letters, 1994 , vol. 35, # 18 p. 2951 - 2954

被引用次数: 14

摘要

Abstract Reaction of 2-alkoxyimmonium methosulfates (2), and of lactam acetals (3) derived therefrom, with α-haloesters in presence of zinc (Reformatsky condition) yielded N-alkyl-2-(α- alkyl-α-alkoxycarbonyl) methylene-1-azacycloalkanes (6), while reaction of 3 with α- haloesters without zinc gave 3-alkoxycarbonylmethyl-1-azacycloalkane-2-one (5). Similar reaction of 2 and 3 with 4-bromoethylquinolin-2-one (4) in presence of zinc gave N-alkyl-2 ...