1-Naphthylpiperazine derivatives as potential atypical antipsychotic agents

…, AA Nagel, HR Howard, PA Seymour…

文献索引：Lowe III; Seeger; Nagel; Howard; Seymour; Heym; Ewing; Newman; Schmidt; Furman; Vincent; Maloney; Robinson; Reynolds; Vinick Journal of Medicinal Chemistry, 1991 , vol. 34, # 6 p. 1860 - 1866

全文：HTML全文

被引用次数: 55

摘要

Discussion The strategy selected to achieve incorporation of the requisite dopamine- blocking activity into the 1-naphthylpiperazine nucleus is based on ideas promulgated some time ago by Ariens. lo Briefly, his approach involves modification of the structure of a receptor agonist, in this case dopamine, with a large lipophilic group on the amino position, which binds to the accessory binding site adjacent to the agonist binding site and ...